Endocrine Abstracts

Worldwide numerous active individuals take phosphodiesterase type 5 inhibitors (PDE-5i), furthermore, to our knowledge, the effects of these drugs on hormone secretion has not been adequately investigated. In particular, considering that a) PDE-5i influence NO bioavailability, b) NO is one of the mediators of the hypothalamus–pituitary–adrenal (HPA) axis response to stress, and, c) physical exercise-related stress activate HPA axis, we investigated whether PDE-5i inf...

Introduction: Obesity is a chronic metabolic condition characterized by an excess of adipose tissue leading to an increased risk of developingdiseases such as diabetes mellitus and cardiovascular pathologies. Unbalanced nutrition and sedentary lifestyle are among the main influencing factors leading to a reduction in muscle mass, strength and functionality, predisposing obese subjects to sarcopenia and functional disability. Moreover, recent studies suggest the possible presen...